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Recent Progress in the Study of Brown Adipose Tissue and Its Scientific Significance
Xuan Yao, Ying Zhang, Shi-Fang Shan, Hao Ying*
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences, Shanghai 200031, China
Abstract: Brown adipose tissue (BAT)， unlike white adipose tissue storing energy in the form of triglycerides， primarily maintains energy balance by burning fat to dissipate surplus energy. Several signaling pathways， nuclear receptors and their co-factors are involved in BAT development and metabolism regulation. Here we briefly summarize the key regulators in the process of brown adipocyte committed differentiation and BAT thermogensis， hoping to elucidate the latest research progress in this field. Besides， we will also discuss the emerging science of BAT therapy as a novel way to combat obesity.
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