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DNA Mismatch Repair and Lung Cancer
Zhi-Wei Zhong, Lin Pan, Xiang-E Long, Yan-Ping Le, Zhao-Hui Gong*
School of Medicine, Ningbo University, Ningbo 315211, China
Abstract: Lung cancer is one of the most common malignant tumors in the world. Although the more studies of the lung cancer are carried out in recent years， the precise mechanism of lung carcinogenesis and development remains unclear. DNA mismatch repair (MMR) is one of the important post-replication repair systems and it plays a crucial role in ensuring DNA replication fidelity， regulating gene mutation and maintaining genome stability. Recent studies demonstrate that MMR system is closely related to lung carcinogenesis， therapy and prognosis. This review mainly focuses on the progress of DNA MMR system in lung cancer.
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