Progress of Studies on Macrophage Alternative Activation and Its Regulation Mechanisms

Abstract: Macrophage is a vital component in innate immune system and plays immunological regulation roles by being bacterial phagocyte and antigen presenting process. Macrophage activation can be described as two forms， classical and alternative. Studies have shown alternative activated macrophage has been involved in many physiological and pathological functions such as tissue remolding， angiogenesis， tumor growth， development and metastasis， inflammation resolution. In this review， we will summarize recent progresses of research in alternative activated macrophage， focusing on its category， phenotype， molecular markers， signaling pathway and important regulatory molecules.

CSTR: 32200.14.cjcb.2011.02.0014