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Chronobiology Research on Mammalian Nutrition and Metabolism
Yin-Hua Ni, Tao Wu, Li Jin, Bo Yu, Fen Zhu-Ge, Zheng-Wei Fu*
College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China
Abstract: Chronobiology is focused on the time mechanism of physiology and behavior which are mainly regulated by the circadian clock. Metabolic processes such as glucose transport to gluconeogenesis， adipogenesis， lipolysis and mitochondrial oxidative phosphorylation are controlled through overlapping transcription networks that are tied to the clock and are thus time sensitive. Conversely， metabolic signals also feed back into the circadian system， modulating circadian gene expression and behavior. Dysregulation of circadian rhythms can contribute to various diseases like cardiovascular disease， obesity， and diabetes. This article briefly reviewed the researches on the interactions between circadian clock and metabolism and nutrition by the relationship between them， the effect of several kinds of nutrition signals and nutrients on biological clock， and the connection of biological clock and metabolic disorders.
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