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Regulation of Wnt Signaling: Mechanisms and Biological Significance
Ding-Zi Yin, Hai-Yun Song*
Key Laboratory of Systems Biology, Chinese Academy of Sciences, Shanghai 200031, China
Abstract: The Wnt signaling pathway is highly conserved during evolution， and plays important roles in animal growth， development， metabolism， and maintenance of stem cells. Misregulation of Wnt signaling contributes to human diseases including cancer， obesity and diabetes. Beta-Catenin and TCF are key regulators in the canonical Wnt pathway， controlling expression of genes involved in growth and metabolism. Here we will discuss the progress in the study of mechanisms that regulate the canonical Wnt pathway， and the implications in human diseases.
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