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Wnt/β-catenin Signaling and Stem Cell Aging
Da-Yong Zhang1,2, Yu-Zhen Tan1*, Hai-Jie Wang1
1Department of Anatomy, and Histology and Embryology, Shanghai Medical School of Fudan University, Shanghai 200032, China; 2School of Medicine and Life Sciences,Zhejiang University City College, Hangzhou 310015, China
Abstract: The Wnt/β-catenin signaling is an evolutionarily conserved signaling pathway which has extensively biological function. Recent researches suggest that the Wnt/β-catenin signaling influences stem cell aging. The Wnt/β-catenin signaling may accelerate the aging of stem cell， and the age-related changes in stem cell may be delayed by altering the Wnt/β-catenin signaling directly. This review focused on the relationship between the Wnt/β-catenin signaling and stem cell aging and the mechanism of the Wnt/β-catenin signaling promoting stem cell aging.
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