Home > Browse Issues > Vol.33 No.1
The Interferon-inducible p204 Protein Regulate Cardiac Differentiation:Mechanisms and Application Prospect
Fang Song, Qiang Wu*
Cardiovascular Institute of Guizhou, Department of Cardiology, Guizhou Province People’s Hospital, Guiyang 550002, China
Abstract: The interferon-inducible protein 200 family (p200) proteins， which have several common characteristic structures and are highly homologous to one another， include 6 kinds of murine and 4 kinds of human family members， are widely involved in regulating cell proliferation and differentiation， senescence and apoptosis， playing important roles in the autoimmune response， anti-virus， anti-cancer and other fields. The endogenous murine p204 of p200 family proteins has the highest expression in heart and skeletal muscle， suggesting that it plays an important role in muscle differentiation. This article links the molecular structure of p204 and its functions of regulation of cell growth and differentiation， describes the mechanisms of p204 to promote skeletal myoblast， embryonal carcinoma cell differentiation and its application prospect for myocardial regeneration after cardiac injury.
CN
EN