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The Molecular Mechanism of IL-1β-induced Articular Chondrocytes Apoptosis
Mu-Dan He1, 2, Xiao-Ping Wang1*, Tong-Sheng Chen2
1Department of Anesthesiology, First Clinical Medical College, Jinan University, Guangzhou 510632, China; 2MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, South China Normal University, Guangzhou 510631, C
Abstract: Osteoarthritis (OA) is a degenerative disease. It shows local， progressive destruction of articular cartilage and joint marginal osteophyte formation， and is accompanied by varying degrees of synovitis. The chondrocytes， which is the only cell type present in mature cartilage， is responsible for the synthesis and update of extracellular matrix and the maintenance of matrix integrity. Although the pathogenesis of OA is not yet clear， an increasing number of studies have found that cytokine interleukin-1β (IL-1β) plays an important role. There are nitric oxide (NO)， reactive oxygen species (ROS)， mitogen-activated protein kinase (MAPK) pathways in IL-1β- induced chondrocytes apoptosis. IL-1β is also an major cytokine for destroying the balance of chondrocytes metabolism in OA progression. Advances in the understanding of the molecular mechanism of IL-1β-induced articular chondrocytes apoptosis may contribute to the discovery of new drugs and the OA therapy.
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