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The Role of INSM1 in Neurosecretory Systems and Pancreatic Islet Development
Yu-Hui You1, Tao Cai2, Xiang Chen1*
1Rehabilitation Department, The 2nd Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, China;2Experimental Medicine Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research,Nati
Abstract: INSM1 (insulinoma associated-1， also known as IA-1) is a transcription factor containing five Zn-finger motifs. Recent reports demonstrated that INSM1 plays an important role in early embryonic neurogenesis and pancreatic islet development. INSM1 has been found highly expressed in many neuroendocrine tumors including insulinoma and medulloblastoma. Further studies of the molecular mechanism of INSM1 in embryonic neurogenesis and pancreatic islet development are helpful for developing novel therapeutic measurements of neuroendocrine diseases and cancers. In this paper， we reviewed a recent progress of INSM1 studies.
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