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The Function of MicroRNA in Embryonic Stem Cells
Xiao-Ying Chen, Zhi-Gang Xue, Guo-Ping Fan*
Stem Cell Research Center, School of Medicine, Tongji University, Shanghai 200092, China
Abstract: MicroRNAs are highly conserved and non-coding small RNAs mainly with 22- nucleotide in length， which regulate gene expression at post-transcriptional levels. MicroRNAs inhibit gene expression either through blocking translation or by promoting degradation of mRNAs. Recent studies suggest that MicroRNAs play important roles in self-renewal and pluripotency of embryonic stem cells. Here we review recent advancement in MicroRNA studies with a focus on the function of MicroRNAs in embryonic stem cells.
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