Effect of Mechanical Factors on Myofibroblast Differentiation and Mechanical Signal Transduction Pathway

Abstract: Myofibroblast is a mutiple origins and heteroplasmic cell， and has an important role in liver fibrosis and wound-healing response. The regulation of myofibroblast differentiation by a variety of cytokines and signaling pathways， mechanical factors and the corresponding mechanical transduction pathway has important impacts on their differentiation. At home and abroad it has become a research hotspot in recent years. In this article， research progress of origins and the mechanical factors which impact the differentiation of myofibroblast， corresponding mechanical transduction pathways， and prospect the cross-talk between mechanical signals and chemical signals in the main direction of development in future are discussed.

CSTR: 32200.14.cjcb.2010.06.0021