Home > Browse Issues > Vol.32 No.6
Progress in Study on 3β-hydroxysteroid-Δ24 Reductase (DHCR24)
Fang-Fang Hou1, Zhen-Qing Liu1, Jian-Li Liu1, Xiang-Yu Cao1, Bing Gao2, Xiu-Li Lu1*
1The School of Life Science, Liaoning University, Shenyang 110036, China;2Shenyang Medical College, Shenyang 110034, China
Abstract: DHCR24 encodes 3β-hydroxysteroid-Δ24 reductase， catalyzing desmosterol to cholesterol. Resent studies suggest DHCR24 is the protein with multiple functions including anti-apoptosis. It exerts anti-neuronal apoptotic function by inhibiting the activity of caspase-3， and functions as the modulators of estrogen， IGF-1 and thyroid hormone when they play the neuronal protective roles and regulate neuronal development. On the other hand， DHCR24 also protects cells from oxidative stress-induced apoptosis through scavenging hydrogen peroxide. These studies suggest DHCR24 plays anti-apoptotic function through multiple pathways. The further studies on the anti-apoptotic role of DHCR24 and its expression regulation will provide new ideas and methods for the therapy of neurodegeneration disease and other common diseases in which oxidative stress contributes to their pathogenesis.
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