Home > Browse Issues > Vol.32 No.6
Latest Advances in the Research and Development of Onconase
Xue Tian1,2, Qing-Cheng Wang2*, Ru-Ling Shen2, Dian-Sheng Xu1, Jian Fei2
1State Key Laboratory of Bioreactor Engineering of East China University of Science and Technology, Shanghai 200237, China;2Shanghai Research Center for Biomodel Organism, Shanghai 201210, China
Abstract: Onconase， a member of RNase A superfamily， is a ribonuclease originally purified from oocytes and early embryo of Nothern leopard frog (Rana pipiens)， which shows striking anti- tumor potential in vitro and in vivo. Onconase has been approved as an orphan drug applied for the treatment of malignant mesothelioma. Onconase has a unique structure and high stability. In clin- ics， it has shown mild side-effects， low immunogenicity and infrequent drug-resistance. Therefore， the research on Onconase possesses both important theoretical and clinically applied value. This paper reviews the latest advances of the studies on its structural characteristics， catalytic specificity， cytotoxicity， antitumor activity and clinical application. Meanwhile some important problems related to Onconase are discussed.
CN
EN