Sumoylation Regulates Membrane Protein Function

Abstract: As a type of important protein post-translational modification， the well-known role of sumoylation is to mediate import/export and activition of transcription-related proteins. In recent years， it was reported that the substrates modified by sumoylation extend to several membrane proteins， such as potassium ion channel， glutamate and kainate receptor subunit， and TGF-β receptor， in additional to nuclear and perinuclear proteins. This review briefly introduces the advances about this newly emerging field of membrane protein function regulated by sumoylation.

CSTR: 32200.14.cjcb.2010.06.0016