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Centrosome: Insight into Carcinogenesis
Ying Chen1*, Yan Zhou1, Li-Yong Huang2, Qing-Zhong Kong3*
1School of Life Science and Technology, Henan Institute of Science and Technology, Xinxiang 453003, China; 2Department of Neurosurgery, the First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China; 3Shan
Abstract: The centrosome functions as the major microtubule nucleating center in animal cells. The two centrosomes ensure the equal division of chromosome into the two daughter cells during cell division. Therefore， defects in centrosome either in the structure or in the function may eventually result in genetic abnormalities， thereby leading to the development of cancer. Since chromosome instability (CIN)， one of the typical characteristics of cancer cells， was mainly caused by abnormal centrosome， and CIN has been closely associated with the development of drug resistance， it is not difficult to imagine how important roles that centrosome plays in carcinogenesis. We， in this article， emphasized the novel roles of centrosome in cell control， particularly the cellular activities that are closely related with carcinogenesis and the development of drug resistance， which is expected to be useful for better understanding the mechanism underlining drug resistance， and for guiding the designs of anticancer agents， and centrosome-associated drugs in particular.
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