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Myristoylated Alanine-rich C Kinase Substrate in Alzheimer，s Disease
Rui Su1, Zhen-Yun Han2*, Yun-Ling Zhang2, Ji-Ping Fan1
1China Academy of Chinese Medical Science, Beijing 100700, China; 2Department of Neurology, Beijing University of Chinese Medicine Dongfang Hospital, Beijing 100078, China
Abstract: myristoylated alanine-rich C kinase substrate (MARCKS) has been suggested to be located in neuron dendritic spines， as the major substrate for protein kinase C (PKC). It mediates the neuron surface signal and actin cytoskeleton， which is closely related with dendritic spines plasticity. The brain of Alzheimer’s disease has significant PKC deficiency and abnormal MARCKS phosphorylation， which are both important for dementia symptom of AD. So， the role of MARCKS and its alteration in learning and memory function of AD will be reviewed in this article.
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