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The RHO Protein Family and Cell Polarity
Ji-Ying Wang, Qing Rao*
State Key Lab of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union of Medical College, Tianjin 300020, China
Abstract: The formation of cell polarity significantly influences the development， differentiation and function of the cells. The loss of cell polarity is tightly associated with tumorigenesis. The Rho family of small G protein is one of the important factors regulating the actin cytoskeleton reorganization， and plays an essential role in coordinating the cell polarity and process of normal morphogenesis. Now we review on the relationship between the Rho family and cell polarity.
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