p53 and Tumor Therapy

Abstract: p53 is one of the known tumor suppressor genes which have the most associativity with the pathogenesis of human tumor. The wild-type p53 participated in DNA damage repair， cell cycle regulation， cell apoptosis and angiogenesis inhibition and other physiological processes. However， mutation of p53 gene would cause the loss of functions mentioned above and lead to tumor formation. With the development of molecular biology techniques， more and more in-depth research was carried out on the tumor suppressor gene of p53. Based on the research of foreign and domestic scholars in recent years， this paper reviewed the relationship between p53 and tumor formation， and its role in tumor therapy.

CSTR: 32200.14.cjcb.2010.04.0025