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Recent Progress in the Study of Polo-like Kinase 4
Jun-Li Xuan, Xiao-Yi Yan, Tian-Hua Zhou*
Department of Cell Biology, School of Medicine, Zhejiang University, Hangzhou 310058, China
Abstract: Polo-like kinase 4 (PLK4)， a member of the Polo family of highly conserved serine/threonine kinases， has been identified as a key regulator of centriole duplication. PLK4 is mainly expressed in actively dividing tissues and cells， but not in resting ones， indicating a role in cell proliferation. In addition， PLK4 is also highly expressed in various cancer cells and is associated with tumorigenesis. In this article， recent findings related to PLK4 were summarized.
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