Generation and Regulation Mechanism of Calcium Signal in Photodynamic Therapy

Abstract: Photodynamic therapy (PDT) is a novel and promising treatment for cancer. Based on injection of a photosensitizer， followed by exposing the cancer to high dosage of light at an appropriate wavelength， then photosenzitizer accumulated in cancer initiates photodynamic reaction to destroy the cancer. Subcellular distribution of different photosenzitizers is different， any organelle can be the target of photosenzitizer， such as mitochondria， endoplasmic reticulum， plasma membrane， lysosome， cytoskeleton and so on. Organelles accumulated photosenzitizers would be firstly destroyed when illumination. As an important signal molecule， calcium signal is involved in the cellular signal transduction procedure and plays an important role in PDT-induced apoptosis. In this study， the generation mechanism of calcium signal was explored from the damnifications of subcellular， and then the regulation mechanism of calcium signal in apoptosis induced by PDT was elucidated concisely.

CSTR: 32200.14.cjcb.2008.01.0008