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Antisense RNA Transcription: An Epigenetic Mechanism for Gene Expressions Regulation
Wei Deng, Qin-Hua Chen, Yi-Mei Fan*, Ya-Ping Wang
Department of Medical Genetics, Medical School, Nanjing University, Jiangsu Key Laboratory of Molecular Medicine, Nanjing 210093, China
Abstract: Antisense RNA (AS-RNA) is a kind of non-coding RNA. Antisense transcription is a widespread phenomenon in the mammalian genome. It is thought to play a role in regulation of gene expression. Recent study confirmed that antisense RNA medicated gene-expression mainly through epigenetic mechanism. The changes of the level of DNA methylation， heterochromatin formation by the histone modification and other non-coding RNA interferences might be related to antisense RNA.
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