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Regulation of Cell Migration in Metastasis of Breast Cancer
Xiao-Hui Chen, Yu-Mei Feng*
Department of Biochemistry and Molecular Biology, Breast Cancer Prevention and Treatment Key Laboratory of Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
Abstract: Cell migration is one of the crucial steps in breast cancer invasion and metastasis. In the process of cell migration， acquisition of the capability of directed migration forced by the reorganization of actin cytoskeleton in regulation of Rho family small GTPases is the primary mechanism. In addition， pleasant local microenvironment provided by the interaction of breast cancer cells and extracellular matrix makes cell migration convenient. Finally， cancer cells are attracted and arrested at the target organs， and proliferate into metastases. Thus， researches of the molecular mechanisms in cell migration may provide novel strategy for anti-metastasis therapy of breast cancer.
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