Relevance Study Between Zebrafish Mid-blastula Transition and Dorsal-ventral Axis Specification

Abstract: Zebrafish mid-blastula transition(MBT) is an important development stage during which the embryo proceeds from the maternal transcripts control to zygotic's， either a significant time point for dorsal-ventral axis specification. The DV region of embryo has been determined by maternal factors deposited in oocyte immediately after fertilization， sequentially these maternal factors activate downstream zygotic DV genes. Factors involved in DV specification take turns together with maternal degradation and zygotic activation. Additionally， Wnt/β-catenin and Wnt/IP3-Ca2+ signal pathway both take part in the DV specification process. Wnt/β-catenin pathway exists preand post- MBT， but its effects to DV specification differ dependent of the stage when it’s overexpressed， Which rasies the particular role of MBT in DV specification. We reviewed recent year study about the maternal and zygotic factors involved in zebrafish DV specification， and give an outline of the pre-MBT/post-MBT signaling pathway mechanism and function of them.

CSTR: 32200.14.cjcb.2010.03.0001