Osteogenic Induction of Bone Marrow-derived Mesenchymal Stem Cells within Strain for Tissue Engineering

Abstract: Bone marrow-derived mesenchymal stem cells (BMSCs) are a population of cells capable of replicating as undifferentiated cells and that have the potential to differentiate to lineages of mesoblastic origin. As such， they represent an important paradigm of multipotent adult stem cells. Cells are a key to tissue engineering， and the character of BMSCs have impacted significantly on the progress of the tissue regeneration and repair. Furthermore， skeleton system is the locomotion part of the organism， and it抯 primary function is supporting; moreover， complex mechanical forces are clearly involved in cell development in vivo. Therefore， it is necessary to investigate the effect of strain on proliferation and differentiation of BMSCs， and may provide increased insight in the role of strain on osteogenic differentiation of BMSCs in vitro and lead to improved strategies in bone tissue engineering.

CSTR: 32200.14.cjcb.2004.06.0014