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Effects and the Mechanism of Nuclear Matrix Attachment Regions on the Transgenic Expression
Tian-Yun Wang, Yu-Rong Chai, Bao-Mei Yuan, Wei-Hong Hou, Le-Xun Xue*
Henan Key Laboratory of Molecular Medicine, Zhengzhou University, Zhengzhou 450052,China
Abstract: Matrix attachment region (MAR) is operationally defined as DNA elements containing AT-rich that bind specifically to the nuclear matrix. When MAR are positioned on either side of the foreign gene， their presence usually results in higher and more stable expression in transgenic plants or cell lines， and reduce the variation of transgenic host， more likely by minimizing gene silencing. This paper reviews the characters and effects of MAR on the gene expression， and several plausible models to explain MAR effects on transgenic expression are also presented.
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