Home > Browse Issues > Vol.26 No.6
Progress in MicroRNA
Chuan-Bing Shi, Jie Zheng*
Institute of Molecular Pathology, Department of Pathology, School of Basic Medicine, Southeast University, Nanjing 210009, China
Abstract: Recently， a class of small non-coding RNAs called microRNAs (miRNAs) has been discovered in many eukaryotes. Some studies show that they are produced by RNase III Drosha and Dicer， and are exported from the nuclear to the cytoplasm by Exportin-5. MiRNAs and small interfering RNA (siRNA) can inhibit target mRNA expression by similar mechanisms. In addition， miRNAs also act as translational repressors through binding the 3' 'untranslated regions of genes. So far， a large amount of studies reveal that miRNAs might play an important role in development and some human diseases.
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