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The Cytoskeleton and Its Signal Regulation in Smooth Muscle Cells
Yun-Hui Cheng, Mei Han*, Jin-Kun Wen
Hebei Laboratory of Medical Biotechnology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China
Abstract: The cytoskeleton of smooth muscle cells (SMC) is a complex and dynamic network， which is an essential cellular structure for cell survive. Rho-associated coiled-coil kinase (ROCK) and Dial， as the downstream targets of Rho， induce the formation of the stress fibres. Protein kinase C plays a key role during the reorganization of cytoskeleton by different isoforms on subcellular location. The Rho and PKC develop cross-talk through Src signal pathway， regulating the cytoskeleton of SMC.
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