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The Relationship of Cytoplasmic Dynein and Neurodegenerative Diseases
Xun-Yan Liu, Tao Sun 1, Tian-Hua Zhou*
Department of Cell Biology, School of Medicine, Zhejing University, Hangzhou 310058, China;1College of Life Sciences, Zhejing University, Hangzhou 310058, China
Abstract: Axonal transport defects are generally recognized as main factor involved in neurodegenerative disease， such as amyotrophic lateral sclerosis， Alzheimer抯 disease， Parkinson抯 disease， Huntington disease and hereditary sensory neuropathy. Cytoplasmic dynein is the major motor driving axonal retrograde transport; therefore the relationship between cytoplasmic dynein and neurodegenerative disease is drawing extensive attention these years. In this article， recent findings related to cytoplasmic dynein and neuron degenerative diseases were summarized.
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