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The Origin， Distribution and Phenotypic Changes of Hepatic Stellate Cells
Shu-Rui Xie, Xiao-Lan Zhang*
Department of Gastroenterology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
Abstract: Hepatic stellate cells (HSC) are protean， multifunctional， and enigmatic cells of the liver. Liver injury activates quiescent HSC to myofibroblast-like phenotype， which play an important role in the development of hepatic fibrosis. The study of HSC on the origin， distribution and phenotypic changes will provide a new direction for the treatment and reversal of hepatic fibrosis.
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