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Autophagy and Tumor Suppressor Gene P53
Fei Chen, Cui-Ping Liu, Meng Li, Ji-Cheng Li*
Institute of Cell Biology, Zhejiang University, Hangzhou 310058, China
Abstract: Autophagy is a dynamic process of protein degradation， which is typically observed during nutrient deprivation. Autophagic cell death is considered programmed cell death type II， whereas apoptosis is programmed cell death type I. Previous studies indicated that autophagy is compromised in various cancers. Recent research revealed that autophagy is regulated by P53， a critical tumor suppressor that is involved in most tumorigenesis. This review focused on the correlation between autophagy and P53.
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