Home > Browse Issues > Vol.26 No.3
Matrix Metalloproteinases in Cancer Progression
LI Bing Hui*, HAN Mei1, WEN Jin Kun1
The Fourth Hospital, Hebei Medical University, Shijiazhuang 050011, China; 1Institute of Basic Medical Science, Hebei Medical University, Shijiazhuang 050017, China
Abstract: In addition to the extracellular， the matrix metalloproteinases (MMPs) have been found recently to process a wide variety of nonmatrix substrates. MMPs are important in the cleavage of a number of growth factors， receptors， angiogenic stimulators and factors that can modulate cellular migration. The cleavage of the nonmatrix substrates by MMPs affects cellular signaling and functions， regulates various cell behaviors with relevance for cancer biology. To better target MMPs for cancer treatment， an appreciation of their many functions is needed.
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