Structure and Function of Eukaryotic DNA Polymerase δ

Abstract: DNA polymerase δ (Polδ) is the core enzyme involved in the replication of DNA in eukaryote cell， and participates in several DNA repair pathways at the time. Polδ is a complex which is consist of several subunits. It has been now purified from mammalian， Schizosaccharomyces prombe and Saccharomyces cerevisiae and their composition of subunits were analyzed. But it is not known clearly. The general functions of Polδ are recognized now. Polδ plays a role in the replication of the whole leading strand， and it is required for the completion of Okazaki fragment synthesis. Otherwise Polδ is also involved in DNA repair. This function of DNA repair can reduce the mutation of DNA， however， the mechanism is not clear now. In the control of Polδ activation the researchers focus on the regulation of several protein factors on the activation of Polδ and regulation of transcription factors on the expression of the catalytic subunit.

CSTR: 32200.14.cjcb.2004.03.0013