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Progress in the Relationship of Suppressors of Cytokine Signaling and Diabetes
Fen Liu, Chun-Yan Wan, Zhi-Qiu Yang, Zheng-Wei Fu*
College of Biological and Environment Engineering, Zhejiang University of Technology, Hangzhou 310014, China
Abstract: The pathogenesis of diabetes is extremely complex. Some researches indicated that the occurrence of diabetes was closely related to the cytokine signaling in the islet cell. Recently， suppressors of cytokine signaling (suppressors of cytokine signaling， SOCSs)， which regulate the cytokine signaling in the islet cell， have been considered to play an important role in the pathological processes related to both type 1 diabetes (type 1 diabetes mellitum， T1DM) and type 2 diabetes (type 2 diabetes mellitum， T2DM). This article briefly reviews the latest progress related to the role and mechanism of SOCSs in diabetes.
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