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GTPase Ran and Its Biological Function
CAO Yun Kao1,2, ZHANG Gui Xue2, CHEN Da Yuan1, SUN Qing Yuan1*
1State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China; 2North-Eastern Agricultural University, Haerbin 100030, China
Abstract: GTPase Ran， which binds to and hydrolyzes GTP， is a critical regulator of many metabolic pathways. It plays roles in many biological aspects of eukaryotes， such as DNA replication， RNA transcription and processing/modification， nucleocytoplasmic transport of RNA and proteins， the entry into and out of mitosis or meiosis， the spindle assembly， the correct chromosome segregation， the nuclear envelope breakdown and re-assembly during the mitosis and meiosis.
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