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Role of JNK-mediated Apoptosis in Development and Diseases
Wen-Juan Xiang, Ying-Jie Zhang, Ming-Wei Zhu, Ming-Fa Li*
School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
Abstract: As a member of the conserved mitogen-activated protein kinase family， JNK has important physiological functions. The signaling pathway mediated by the well regulated JNK has been implicated in many cellular processes， such as cell growth， apoptosis， cell motility， metabolism and DNA repair. However， the dysregulated JNK signaling could induce many diseases， like ischemia/reperfusion， neurodegenerative diseases， deafness or cancer. Great progresses and major breakthrough have been made recently in this field. In this review， we will mainly focus on the role of JNK signaling in apoptosis， and the significance of such apoptosis in normal development and pathogenesis of the relevant diseases.
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