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Recent Advances in Studies of Erythoid Krüppel-like Factors
XIA Yun, QIAN Ruo Lan1*
School of Life Science, East China Normal University, Shanghai 200062, China; 1 Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China
Abstract: The β-globin gene family has been used as a model for study of gene expression and regulation in eukaryotic cells. These genes expressed specifically in erythroid tissue and differentially expressed in a precise temporal order during development. It has been shown that interaction of erythroid specific trans-acting factors with cis-acting elements may play an important role in regulation of globin gene expression. Here we mainly focus on introducing three erythroid specific factors of KLF family (EKLF， FKL and FKLF-2)， including their structure， fuction and interaction with other trans-acting factors. Previous studies have revealed that they may be critical in the developmental regulation of globin gene expression.
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