Home > Browse Issues > Vol.31 No.1
The Studies of RKTG Function
Yan Chen*, Xiao-Duo Xie
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Abstract: RKTG (Raf kinase trapping to Golgi)， also called PAQR3， belongs to the PAQR (progesterone and adipoQ recepoter) superfamily. It is a type 3 membrane protein specifically localized at the Golgi apparatus with 7 trans-membrane domains. RKTG was recently characterized as a negative regulator of the Ras/Raf/MEK/ERK mitogenic pathway via sequestrating B-Raf and/or C-Raf to the Golgi apparatus. In RKTG-deleted mice， the cell proliferation capability was enhanced in keratinocytes with elevated Raf/MEK/ERK kinase activities. Deficiency of RKTG could also promote skin carcinogenesis in the mouse. In summary， RKTG acts to suppress activation of Ras/Raf/MEK/ERK signaling pathway in vitro and in vivo， and negatively regulate cell proliferation upon mitogenic or oncogenic stimulation.
CN
EN