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Association between Polymorphisms of IL-1 and TNF-α Genes and H.pylori-associated Gastroduodenal Diseases
Yu Xiang1, Zhi-Bang Yang1*, Pu Chen2, Gui-Rong Fan1, Li-Yuan Guo1, Feng Cheng1
1Department of Pathogen Biology, Institute of Neuroscience, Experimental Teaching Center of Basic Medical Sciences,The College of Basic Medical Sciences, Chongqing University of Medical Sciences, Chongqing 400016, China;2Medical Labo
Abstract: To discuss the polymorphisms of IL-1 and TNF-α genes and their association with H.pylori-associated gastroduodenal diseases in Han people in Chongqing， H.pylori-positive 68 patients with H.pylori-associated gastroduodenal diseases (38 chronic gastritis， 30 duodenal ulcer) and 70 healthy controls with H.pylori positive were genotyped for IL-1B-511， TNF-A-308， TNF-A-857 and IL-1RN gene polymorphisms by the PCR-RFLP method. The results indicated that the frequencies of TNF-A-308 genotypes in chronic gastritis group were significantly different compared with control group (χ2=22.614， P<0.001)， and TNF-A-857 genotypes in duodenal ulcer group were significantly different too (χ2=9.444， P=0.009). Multivariate logistic regression analysis showed that the subjects carrying the TNF-A-308 A/A genotype were at a 22-fold elevated risk for chronic gastritis (OR=22.70， 95% CI: 2.51-205.40) compared with the subjects carrying TNF-A-308G/G. The subjects carrying the TNF-A-857 T/T genotype were at a 6-fold elevated risk for duodenal ulcer (OR=6.73， 95% CI: 1.71-26.53) compared with the subjects carrying TNF-A-857 T/T. The results suggest that the polymorphism of TNF-α gene has close association with H.pylori-associated gastroduodenal diseases.
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