Mitochondrial Changes and Role in Apoptosis

Abstract: mitochondrion takes place in great changes in structure and function including the release of proapoptotic factors (such as cytochrome c， apopotosis inducing factor)， loss of mitochondrial transmembrane potential， changes in electron transport， altered cellular oxidation-reduction etc， when cells are induced to undergo apoptosis by apoptotic stimuli. Transcriptional factors involve in the regulation of apoptosis through locating in mitochondrion. Mitochondrion play a role in central function on mammalian cell apoptosis. Recent studies revealed that mitochondrion has close relation with insect cell apoptosis. Mitochondrial function on apoptosis may be of universal significance.

CSTR: 32200.14.cjcb.2005.02.0005