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Regulatory Mechanism and Biological Function of 14-3-3 Protein Family
Jia-Fa Wu, Qiao Wu*
The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China
Abstract: The 14-3-3 proteins are a family of highly conserved regulatory molecules expressed in all eukaryotic cells， which act mainly as either homodimers or heterodimers. The 14-3-3 proteins interact with two targeting proteins or two different domains in one targeting protein simultaneously. The regulatory function of 14-3-3 proteins is mainly mediated by phosphoserine/phosphothreonine motifs. In the present review， the 14-3-3 proteins recognition sequences， the interaction of 14-3-3 proteins with its ligand and the regulatory functions of 14-3-3 proteins in cell cycle， apoptosis， signal transduction and mitochondria/chloroplast precursor proteins import are summarized.
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