Study on the Pathogenesis of RNA Splicing Complex Mutation in Myelodysplastic Syndrome
HU Fang, LIANG Yang*
MDS (myelodysplastic syndrome) is a hematologic malignancy with relatively high incidence in aged people, which has few effective targeted drugs and is difficult to cure unless hematopoietic stem cell transplantation. RNA splicing complex mutation is a high-frequency mutation identified in MDS patients in recent years. Investigating the pathogenic mechanisms of the mutations of RNA splicing complex not only enhances the understanding of the pathogenesis and progression of MDS, but also provides a critical scientific foundation for developing possible targeted drugs. This study intends to review the pathogenesis, translational research and prognostic value of RNA splicing complex mutation in MDS in order to provide theoretical basis for individualized diagnosis and treatment of patients with MDS.
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