Research Progress on Nasopharyngeal Carcinoma Screening
WU Zhicong, LI Tong, CHEN Hua, YE Junping, ZHOU Hangning, MA Zheng, PENG Yinan, CAO Sumei*
NPC (nasopharyngeal carcinoma) has a distinct geographical distribution worldwide, with a notably high incidence in southern China. Population-based screening is crucial for NPC prevention and control in high-incidence regions. China has achieved significant progress in NPC screening, establishing an etiological link between EBV (Epstein-Barr virus)-related biomarkers and the increased risk of NPC through longitudinal studies in high-risk cohorts. This has provided a foundation for developing effective screening strategies. Current population-based screening trials, utilizing dual antibody (VCA/EBNA1-IgA) EBV testing, have demonstrated thatan increased early detection rates for NPC cases, and reduced NPC mortality in screening regions, alongside favorable cost-effectiveness. Emerging screening and triage markers offer potential to further enhance screening efficacy, moving toward precision screening. This review summarizes the history and latest advancements in NPC screening, aiming to support NPC prevention and improve screening effectiveness.
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