Regulation of Bone Metabolism and Multiple Bone Diseases by FOXK1
XU Xuetong, WU Dongdong, YANG Guanghui, ZHANG Miao*
With the aging population and changes in lifestyle, the prevalence of osteoporosis and other bone-related diseases has been steadily increasing. Currently, the treatment for bone diseases primarily relies on pharmacological approaches. However, medications often come with side effects, which can lead to secondary diseases. Therefore, exploring new therapeutic targets has become one of the hot research topics in the medical field. FOXK1 (Forkhead box K1) is an important member of the FOX family. It contains a DNA-binding domain and a FHA (Forkhead-associated domain), which interacts specifically with other proteins to activate transcriptional programs that regulate cell proliferation and survival. However, its role in bone metabolism and bone-related diseases has been less explored. This review systematically discusses the regulatory role of FOXK1 in bone metabolism, revealing its molecular mechanisms in modulating osteoblast and osteoclast activity, thereby affecting the balance between bone formation and resorption. Furthermore, the review explores its potential involvement in bone-related diseases. The findings suggest that FOXK1 can promote osteoblast differentiation by inducing aerobic glycolysis.
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