The Role and Application of Heat Shock Protein in Diabetes Nephropathy
DENG Xiaozheng, LIU Ling, WANG Wenhai, WEN Shaojin, ZHANG Wanting*
Diabetes nephropathy is one of the common complications of diabetes, which is mainly due to the long-term hyperglycemia state leading to changes in renal structure and function. HSPs (heat shock proteins) are a class of biomolecules that increase in expression under stress conditions and have the function of protecting cells from damage. HSPs play an important role in diabetes nephropathy, and are expected to be used as biomarkers and potential therapeutic strategies for renal diseases. Research has shown that heat shock proteins can play a role by reducing oxidative stress, inhibiting inflammatory processes, and protecting kidney cells from damage. It can improve renal function and delay the progress of diabetes nephropathy by using the antioxidant, anti-inflammatory and anti apoptosis mechanisms of heat shock protein. This article reviews the research status of heat shock protein in diabetes nephropathy, and looks forward to the future research directions, including in-depth study of its molecular mechanism, development of new diagnostic methods and treatment strategies.
CN
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