Survival Strategy of Legionella pneumophila: Hijacking Small GTPases to Manipulate Host Vesicle Trafficking
LI Youzhi1,2, CHEN Taotao1,2, OUYANG Songying1,2, ZHANG Dandan1,2*
L. pneumophila (Legionella pneumophila), as the causative agent of legionellosis, invades host cells and secretes more than 330 effector proteins to interfere with the life activities of host cells, thereby establishing a niche required for its replication, called the LCV (Legionella-containing vacuole). The formation and maturation of LCV is essential for the survival of L. pneumophila in host cells. The small GTPases, as a molecular switch, participates in the process of cellular vesicle transport. In the past decade, numerous studies have shown that host small GTPase proteins play an important role in the recruitment of host vesicles by L. pneumophila. L. pneumophila manipulates host vesicle trafficking by its secreted effector proteins involved in modulating the activity of host small GTPase, thus hijacking host vesicles. This study focuses on reviewing the small GTPase, L. pneumophila, and the molecular mechanisms by which L. pneumophila regulates the small GTPase, providing reference for further understanding of the pathogenesis of L. pneumophila.
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