The Biological Role of Circular RNA in Doxorubicin-Induced Cardiotoxicity
BU Jiale1,2, WANG Yuqin1,2, XIE Yixin1,2, CHEN Jianshu1,2, LI Yongnan1,3, ZHANG Xiaowei1,2*
circRNAs (circular RNAs) are a class of non-coding RNA molecules characterized by their covalent circular structure, arising from linear precursor mRNAs via a back-splicing mechanism. These endogenous transcripts have been implicated in the regulation of various pathophysiological processes in cardiomyocytes, such as proliferation, migration, differentiation, senescence, and apoptosis, playing significant roles in cardiovascular diseases including atrial fibrillation, atherosclerosis, myocardial infarction, heart failure, hypertrophic cardiomyopathy, and dilated cardiomyopathy. Doxorubicin, a chemotherapy agent widely used in cancer treatment, is notably limited in clinical application due to its cardiotoxicity. Numerous studies suggest a profound association between circRNAs and doxorubicin-induced cardiotoxicity. They participate not only through molecular mechanisms like acting as competitive endogenous RNAs and interacting with proteins but also by engaging in cellular biological processes including oxidative stress, apoptosis, pyroptosis, autophagy, and ferroptosis. This paper provides a detailed account of the formation and biological functions of circRNAs, summarizing their biological roles in doxorubicin-induced cardiotoxicity, thereby offering a novel research foundation and theoretical support for the treatment of doxorubicininduced cardiotoxicity.
CN
EN