Biological Function of HAX1 and Its Relationship with Clinical Diseases

LIU Yang¹, ZHANG Xinyu^1,2, RONG Qiong^1,3, QI Mingyue¹, GUO Hui^1,3*

(¹School of Medicine, Kunming University of Science and Technology, Kunming 650032, China; ²Regenerative Medicine Research Center, the First People’s Hospital of Yunnan Province, Kunming 650032, China; ³Center of Stomatology, the First People’s Hospital of Yunnan Province, Kunming 650032, China)

Abstract:

HAX1 (human HCLS1-associated protein X-1) is a protein existing widely in the body that can interact with various proteins and perform many biological functions. The HAX1 gene undergoes selective splicing during the transcription process, leading to the formation of multiple splicing variants. The HAX1 protein subtype produced by the translation of its splicing variant 001 has been extensively studied, and plays a key role in antiapoptosis, cell migration promotion, regulation of intracellular Ca2+ homeostasis, regulation of oxidative stress, autophagy, maintenance of mitochondrial protein homeostasis, participating in angiogenesis and regulation of signal transduction. Abnormal expression or mutation of HAX1 can lead to the occurrence and development of various diseases. This article aims to systematically elucidate the biological function, and the relationship of HAX1 with clinical diseases, desiring to provide the basis for in-depth research on its functional mechanism and to assist in the treatment of diseases related with HAX1.

CSTR: 32200.14.cjcb.2024.05.0018