Research Progress on the Impact Mechanism of Ferroptosis on Intervertebral Disc Degeneration
ZHANG Yanjun1#, LIU Yandong2#, DENG Qiang1*, GUO Tiefeng1, LI Jiaming1, TAN Sheng2, LUO Linzhao1
IVDD (intervertebral disc degeneration) is a degenerative disease of the spine, most commonly found in the lumbar and cervical vertebrae. It is characterized by a decrease in water and protein content in the intervertebral disc tissue, leading to disc wear, pain, loss of elasticity, and displacement, which can cause various spinal diseases. The academic community has conducted many studies on IVDD, among which ferroptosis is one of the key mechanisms in the process of intervertebral disc degeneration. Cells determine whether to further accumulate large amounts of iron ions through intracellular iron concentration and autophagy pathways. Excessive iron can lead to increased free radical activity, causing damage to cell membranes, proteins, and other cellular structures, thereby promoting cell death and tissue destruction. At present, there are few effective drugs for treating IVDD, but targeting ferroptosis may be a new approach and method for treating IVDD. This review provides an in-depth explanation of the mechanism of iron death induced IVDD and its interactions with other factors, and explores more effective prevention and treatment strategies for IVDD based on iron death.
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