Research Progress on the Mechanism of Exercise Regulating miRNAs to Improve the Non-Alcoholic Fatty Liver Disease
LIAO Chunwang1, HU Xuefeng2, LIU Zuhui1*
NAFLD (non-alcoholic fatty liver disease) is a common type of chronic liver disease, including non-alcoholic simple fatty liver, non-alcoholic steatohepatitis, etc. It is often complicated with other metabolic diseases, which seriously affects human health. As an effective way to prevent and treat NAFLD, exercise can regulate the expression of related miRNAs to target lipid metabolism, inflammation, oxidative stress, hepatocyte apoptosis, and hepatic tissue fibrosis in the course of NAFLD. The article combed through the previous research results and elaborated on the role of relevant miRNAs in the process of improvement of NAFLD by exercise, explored the relationship between exercise, miRNA, NAFLD, and the mechanism of exercise regulating miRNA expression to improve NAFLD, with a view to providing a reference for the exploration of the mechanism of exercise intervention in the treatment of NAFLD.
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