Effects of Mitochondrial Dysfunction on Cognitive Function
TU Jingyi, WANG Shicheng, SHEN Changqing, LI Lang, PENG Siqi, LEI Ruiling, QIU Xiaoyan*
Cognition refers to the ability of individuals to correctly establish connections between things and make a response in a complex and changing environment. Research on mice cognitive functions makes a foundation for the development of medicine of human cognitive impairments, and recent studies show that the cognitive function of livestock has a great influence on their reproduction, production and their offspring survival, therefore, it is necessary to investigate its regulation mechanisms. In recent years, the correlation between mitochondria and cognitive function has become a hot topic at home and abroad. This paper summarizes the influences of the mitochondrial dysfunctions on cognition from oxidative stress, calcium disorder, permeability transformation, biosynthesis, DNA mutation, fission and fusion, autophagy defects and mitochondrial transport in neurons, laying the foundation for comprehensively understanding of neural regulation mechanism of cognitive functions and providing an important theoretical basis for the development of drugs for cognitive disorders from the perspective of mitochondria.
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